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Related Experiment Videos

Corneal ulcers in Nepal

M P Upadhyay, N C Rai, F Brandt

    Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
    |January 1, 1982
    PubMed
    Summary
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    Corneal ulcers in Kathmandu disproportionately affected females, often linked to vegetative trauma. Bacterial and fungal infections were identified, with specific antibiotics showing effectiveness in vitro.

    Area of Science:

    • Ophthalmology
    • Microbiology
    • Public Health

    Background:

    • Corneal ulcers represent a significant cause of visual impairment globally.
    • Understanding the etiology and causative agents of corneal ulcers is crucial for effective treatment and prevention strategies.
    • Geographical and seasonal variations in corneal ulcer incidence and microbial profiles are well-documented.

    Purpose of the Study:

    • To investigate the epidemiological characteristics of corneal ulcers in Kathmandu, Nepal.
    • To identify the microbial pathogens responsible for corneal ulcer infections.
    • To determine the in vitro antimicrobial susceptibility patterns of isolated bacteria and fungi.

    Main Methods:

    • A prospective study involving 133 patients with corneal ulcers in Kathmandu, Nepal.

    Related Experiment Videos

  • Clinical examination and scraping of corneal ulcers for microbiological analysis.
  • In vitro sensitivity testing of bacterial and fungal isolates against various antimicrobial agents.

    • Main Results:

    • Corneal ulcers were more prevalent in females of active age, particularly during monsoon and autumn.
    • Trauma from vegetative matter was the most common preceding factor.
    • Microorganisms were isolated in 50% of cases, with bacteria accounting for 75% and fungi for 25% of positive cultures.
    • Effective antibacterial agents included carbenicillin, chloramphenicol, cephaloridine, methicillin, and lincomycin.
    • Clotrimazole demonstrated efficacy against fungal isolates.

    Conclusions:

    • Corneal ulcers in Kathmandu exhibit distinct epidemiological patterns, with a notable association with vegetative trauma.
    • Bacterial and fungal pathogens are significant contributors to corneal ulcerations in this region.
    • The identified antimicrobial sensitivities provide valuable guidance for empirical and targeted treatment of corneal ulcers.