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Nitrosamines and rubber

B Spiegelhalder, R Preussmann

    IARC Scientific Publications
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Occupational exposure to N-nitrosamines in the rubber industry is linked to specific chemicals. Reducing nitrosating agents or changing rubber chemicals significantly lowers nitrosamine levels in products and workplaces.

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    Area of Science:

    • Industrial Hygiene
    • Chemical Toxicology
    • Occupational Health

    Background:

    • N-nitrosamine exposure in the rubber industry was initially identified in 1979.
    • Rubber compounding chemicals derived from secondary amines are sources of nitrosamines.

    Purpose of the Study:

    • To investigate the origin and formation of nitrosamines in the rubber industry.
    • To identify sources and formation pathways of nitrosamines in rubber products and workplace air.

    Main Methods:

    • Analysis of chemicals used in rubber compounding.
    • Testing of industrial rubber products for nitrosamine content.
    • Monitoring of airborne nitrosamine concentrations in work areas.

    Main Results:

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    • Nitrosamines were detected in rubber compounding chemicals and finished products.
    • Airborne nitrosamines were found in manufacturing and storage areas, corresponding to compounded chemicals.
    • Initial nitrosamine levels in chemicals were insufficient to explain levels in products and air, indicating additional nitrosation.

    Conclusions:

    • Secondary amine derivatives in rubber chemicals are primary sources of nitrosamines.
    • Additional nitrosation processes contribute to elevated nitrosamine levels.
    • Eliminating nitrosating agents or altering rubber chemicals can substantially decrease nitrosamine contamination.