Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proliferative responses of rabbit lymphocytes to Pasteurella multocida decrease with prolonged immunization

E Skaletsky, L B Corbeil, A Wunderlich

    Infection and Immunity
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of surface antigen TF1.17 in feline Tritrichomonas foetus isolates.

    Veterinary parasitology·2017
    Same author

    Effect of Histophilus somni on Heart and Brain Microvascular Endothelial Cells.

    Veterinary pathology·2017
    Same author

    Serum, uterine, and vaginal mucosal IgG antibody responses against Tritrichomonas foetus after administration of a commercial killed whole T foetus vaccine in beef cows.

    Theriogenology·2016
    Same author

    Diatoms and diatomaceous earth as novel poultry vaccine adjuvants.

    Poultry science·2016
    Same author

    Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.

    International journal of surgery case reports·2016
    Same author

    Histophilus somni Stimulates Expression of Antiviral Proteins and Inhibits BRSV Replication in Bovine Respiratory Epithelial Cells.

    PloS one·2016
    Same journal

    The cholesterol-dependent cytolysin promotes <i>Streptococcus</i> systemic spread and induces arachidonic acid accumulation-mediated lethality in a murine intraperitoneal infection model.

    Infection and immunity·2026
    Same journal

    Phenotypic and genotypic analysis of <i>Candida albicans</i> vaginal isolates reveals that <i>ECE1</i> expression underpins pathogenicity.

    Infection and immunity·2026
    Same journal

    <i>Staphylococcus aureus</i> pore-forming toxins differentially shape disease severity in experimental endophthalmitis.

    Infection and immunity·2026
    Same journal

    Group B streptococcal membrane vesicles induce proinflammatory responses in neonatal meninges.

    Infection and immunity·2026
    Same journal

    <i>Pseudomonas aeruginosa</i> infection causes lysosomal dysfunction in the cystic fibrosis bronchial epithelium.

    Infection and immunity·2026
    Same journal

    The role of probiotics in restoring and maintaining vaginal microbiome health: a review.

    Infection and immunity·2026
    See all related articles

    Repeated immunizations with Pasteurella multocida suppressed the blastogenic response of rabbit lymphocytes to the antigen. This indicates a potential desensitization or regulatory mechanism following repeated exposure.

    Area of Science:

    • Immunology
    • Microbiology

    Background:

    • Pasteurella multocida is a significant pathogen in veterinary medicine.
    • Understanding immune responses to bacterial antigens is crucial for vaccine development.

    Purpose of the Study:

    • To investigate the in vitro blastogenic response of rabbit lymphocytes to Pasteurella multocida.
    • To determine the effect of varying immunization schedules on this immune response.

    Main Methods:

    • Peripheral blood and splenic lymphocytes were isolated from rabbits.
    • Lymphocytes were stimulated in vitro with Pasteurella multocida antigen.
    • Blast transformation was measured as an indicator of immune response.

    Main Results:

    • Lymphocytes from immunized rabbits showed blast transformation in response to Pasteurella multocida.

    Related Experiment Videos

  • Repeated immunizations led to a suppression of this blastogenic response.

    • Conclusions:

    • The study demonstrates an in vitro lymphocyte proliferation assay for Pasteurella multocida.
    • Repeated antigen exposure can lead to suppressed cellular immune responses, suggesting immune tolerance or regulation.