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Angiographic nephrectomy using iodinated contrast agent

T M Brady, D Singer, C A Weiss

    Investigative Radiology
    |September 1, 1982
    PubMed
    Summary
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    Contrast staining using Diatrizoate meglumine and sodium (Renografin-76) in obstructed renal arteries led to significant renal tissue destruction and reduced renin output in dogs. This method proved effective for uniform renal infarction.

    Area of Science:

    • Nephrology
    • Radiology
    • Experimental Pathology

    Background:

    • Renal artery obstruction can lead to significant kidney damage.
    • Effective methods for controlled renal tissue destruction are of interest in experimental research.

    Purpose of the Study:

    • To evaluate the efficacy of contrast staining with Diatrizoate meglumine and sodium (Renografin-76) for inducing renal infarction in an obstructed canine renal artery model.
    • To assess the impact of contrast staining on renal function, specifically renin output, and long-term renal morphology.

    Main Methods:

    • Diatrizoate meglumine and sodium (Renografin-76) was infused into the obstructed renal artery of 13 dogs.
    • Contrast accumulation ('contrast staining') was monitored, with repeat injections as needed.
    • Renin output was measured, and angiography was performed at 14-18 weeks to assess renal size and vascularity.

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    Main Results:

    • Intense and prolonged contrast staining was achieved in all experimental kidneys.
    • Renin output from stained kidneys was significantly lower compared to contralateral kidneys.
    • Angiography revealed marked renal size reduction, with two dogs showing complete renal artery occlusion and no collateral circulation.
    • Histological examination confirmed diffuse renal infarction with coagulative necrosis.

    Conclusions:

    • Contrast staining with Diatrizoate meglumine and sodium is an effective method for achieving uniform destruction of renal tissue.
    • This technique results in significant renal infarction and reduced renal function, as evidenced by decreased renin output and renal atrophy.