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Glycosylation of proteins in developing human brain

T Korpeinen, I Mononen, T Krusius

    Journal of Neurochemistry
    |December 1, 1982
    PubMed

    Insights

    Human brain glycoprotein carbohydrate content significantly increases during development, reaching adult levels by 5 postnatal months. This study tracks monosaccharide concentrations from fetal stages through infancy.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Biochemistry

    Background:

    • Glycoproteins are crucial for brain structure and function.
    • Understanding developmental changes in brain composition is vital.

    Purpose of the Study:

    • To investigate the developmental changes in human brain glycoprotein carbohydrate content.
    • To quantify monosaccharide concentrations during fetal and early postnatal development.

    Main Methods:

    • Analysis of human brain tissue from 12 fetal weeks to 8 postnatal months.
    • Quantification of glycoprotein monosaccharide concentrations.

    Main Results:

    • All measured glycoprotein monosaccharides increased with age.
    • A 150% rise in total glycoprotein monosaccharides occurred from the third fetal month to delivery.
    • Adult levels were attained by the fifth postnatal month.

    Conclusions:

    • Significant developmental increase in brain glycoprotein carbohydrates occurs primarily during late gestation.
    • Postnatal brain development shows a slower accumulation of these carbohydrates.

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