In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells

A pharmacokinetic model for triazinate uptake in L-1210 cells in mice and W-256 cells in rats was developed to describe the observed concentration profiles with time in these cells following a 36 mg/m2 ip injection. The L-1210 cell permeability to triazinate was found to the approximately or 15 times smaller compared with W-256 cells. Similarly, the partition coefficient for L-1210 cells was calculated to be approximately or 175 times smaller than for W-256 cells. Cell membrane permeability appears to be the key parameter determining the drug transport at a short time after injection.