Related Experiment Video
Updated: Aug 9, 2026

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine
Published on: February 9, 2016
Circulatory dose-response effects of hydrochlorothiazide at rest and during dynamic exercise in essential
Abstract:
The immediate and sustained circulatory effects of hydrochlorothiazide were evaluated at rest and during dynamic exercise in 24 patients with essential hypertension. Twenty-four hours after the first dose (50mg) there was a reduction in the resting systolic blood pressure, with attenuation of exercise tachycardia. During sustained therapy at two dose levels (50mg and 100mg), each of one month's duration, the systolic and diastolic blood pressure were reduced, both at rest and during dynamic exercise, without substantial difference between the two doses. Exercise tachycardia was attenuated during longterm treatment, without alteration of the pressor responses to exercise. The reduction in exercise tachycardia at the same workload in this study suggests that thiazides, in addition to their diuretic action, have a vascular component that augments the fall in systemic vascular resistance during dynamic exercise.
More Related Videos
10:21Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
Published on: September 22, 2023
07:49A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
Related Concept Videos
Antihypertensive Drugs: Action of Diuretics
Antihypertensive Drugs: Thiazide-Class Diuretics
Heart Failure Drugs: Diuretics
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Hypertension II: Pathophysiology