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[Muscle irritation study on T-1982]

H Nakada, Y Takimoto, Y Kawamura

    The Japanese Journal of Antibiotics
    |September 1, 1982
    PubMed
    Summary
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    The intramuscular injection of T-1982 in rabbits showed a local irritation effect comparable to 0.75% acetic acid. This study determined T-1982

    Area of Science:

    • Pharmacology
    • Toxicology
    • Preclinical Research

    Background:

    • Intramuscular injections can cause local tissue reactions.
    • Evaluating the local irritation potential of new drug formulations is crucial for safety.

    Purpose of the Study:

    • To assess the local irritation effect of T-1982 following intramuscular injection in rabbits.
    • To compare the irritation potential of T-1982 with saline and acetic acid solutions.

    Main Methods:

    • T-1982 was administered via single intramuscular injection into the musculus vastus lateralis of rabbits.
    • Muscle injury was evaluated at 2 and 7 days post-injection using muscle weight ratio, gross observation, and histological analysis.
    • Comparisons were made against saline, 0.75% acetic acid, and 6% acetic acid controls.

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    Main Results:

    • T-1982 demonstrated a local irritation effect.
    • The muscular injury caused by T-1982 was found to be similar to that of 0.75% acetic acid.
    • T-1982 induced milder irritation compared to 6% acetic acid.

    Conclusions:

    • The local irritation effect of T-1982 was classified as grade 3.
    • T-1982 exhibits a moderate local irritation profile upon intramuscular administration.