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Mebendazole paste as an anthelmintic in random source research cats
Laboratory Animal Science
|October 1, 1982
Summary
Mebendazole paste effectively removed common feline parasites like hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) in cats. Studies showed high efficacy with no observed toxic side effects across various dosages.
Area of Science:
- Veterinary Parasitology
- Feline Medicine
- Pharmacology
Background:
- Gastrointestinal nematodes and cestodes are common in domestic cats, posing health risks.
- Mebendazole is a broad-spectrum anthelmintic, but its efficacy and safety in cats require specific investigation.
Purpose of the Study:
- To evaluate the efficacy and safety of mebendazole paste in treating natural infections of Ancylostoma tubaeforme, Toxocara cati, and Dipylidium caninum in cats.
Main Methods:
- Cats with natural infections were treated orally with mebendazole paste daily for 3 days at doses of 11 mg/kg, 22 mg/kg, or 33 mg/kg.
- Efficacy was assessed by parasite egg counts and worm recovery.
- Clinical observations monitored for any adverse effects.
Main Results:
- Mebendazole paste at 22 mg/kg and 33 mg/kg achieved high efficacy against Ancylostoma tubaeforme (95.5%-98%).
- Doses of 11 mg/kg, 22 mg/kg, and 33 mg/kg were 100% effective against Toxocara cati.
- Efficacious against Dipylidium caninum at 11 mg/kg and 22 mg/kg.
- No toxic side effects or clinical illness were observed in treated cats.
Conclusions:
- Mebendazole paste is a highly effective and safe anthelmintic for treating common gastrointestinal parasites in cats.
- Specific dosages demonstrate excellent efficacy against hookworms, roundworms, and tapeworms.