Related Experiment Videos
Steroid receptors in kidney tumours
Progress in Clinical and Biological Research
|January 1, 1982
Summary
Androgen and oestrogen receptors are present in human kidneys. Malignant kidneys show higher androgen receptor concentration, while oestrogen receptors are more common in kidney tumors than normal tissues.
Area of Science:
- Endocrinology
- Urology
- Oncology
Background:
- Androgen and oestrogen receptors play roles in normal kidney function and development.
- Their presence and role in malignant kidney diseases are not fully understood.
Purpose of the Study:
- To investigate the presence and characteristics of androgen and oestrogen receptors in normal and malignant human kidney tissues.
- To compare receptor levels between normal and cancerous kidney samples.
Main Methods:
- Tissue samples from normal and malignant human kidneys were analyzed.
- Receptor characterization was performed using glycerol gradient centrifugation and isoelectric focusing.
Main Results:
- Androgen receptors were detected in 40% of kidney tissues, with higher concentrations in malignant samples.
- Oestrogen receptors were found in 8 out of 9 tumors but only 1 out of 7 normal kidneys, and at very low levels.
Conclusions:
- Both androgen and oestrogen receptors are present in human kidneys.
- Malignant kidney tissues exhibit distinct patterns of androgen and oestrogen receptor expression compared to normal tissues, suggesting potential roles in kidney cancer.