Newer phenothiazines as anticonvulsants and monoamine oxidase inhibitors

Eight new compounds have been synthesised in the series of 10-(alpha-aminoacylhydrazinoacetyl)phenothiazines. Their structures have been confirmed by elemental analysis and IR spectroscopic studies. The compounds have been found to possess the protection of mice against chemoshock- and electroshock-induced seizures and the monoamineoxidase (MAO) inhibitory activity. A good correlation between these two activities and the structure of the compounds has been found.