[Effect of pH and activation on the arginase activity of rat liver treated with thioacetamide]

Arginase (E.C. 3.5.3.1) activity of liver from thioacetamide treated rats has been investigated in relation to 6.5 pH in the reaction medium, as well as stability against activation process. The results suggest that thioacetamide damage affects enzyme protein at the level of ionizing groups of active center and/or binding to Mn2+.