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Related Experiment Videos

Maternal medication does temporarily affect neonatal neurobehaviour

J G Brock-Utne, A Moosa, E Mankowitz

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |December 18, 1982
    PubMed
    Summary
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    Maternal medication during labor temporarily impacts newborn behavior, affecting tone and reflexes. The KEH scale effectively detects these subtle, short-term effects in neonates.

    Area of Science:

    • Neonatal assessment
    • Neurobehavioral development
    • Pharmacology in pregnancy

    Background:

    • Maternal medication during labor can influence neonatal behavior.
    • Subtle neurobehavioral changes in newborns may be difficult to detect.
    • The KEH scale is a modified neurodevelopmental assessment technique.

    Purpose of the Study:

    • To evaluate the effect of maternal medication on newborn behavior using the KEH scale.
    • To determine if the KEH scale can detect subtle neurobehavioral changes in neonates.
    • To assess the duration of maternal medication's impact on infant behavior.

    Main Methods:

    • The KEH scale was administered to 60 healthy newborns at 2-4 hours and 24 hours of age.
    • Infants were divided into two groups: those whose mothers received medication during labor and those who did not.

    Related Experiment Videos

  • Neonatal tone, rooting, reflexes, and overall neurobehavioral scores were assessed.

    • Main Results:

    • Neonates exposed to maternal medication showed significantly depressed tone, rooting, reflexes, and total neurobehavioral scores at 2-4 hours.
    • No significant differences in neurobehavioral scores were observed between the groups at 24 hours.
    • Apgar scores were similar for both groups at both time points.

    Conclusions:

    • The KEH scale is sensitive to subtle, transient effects of maternal medication on neonatal behavior.
    • This assessment tool may be valuable for evaluating the impact of drugs and anesthetics administered to mothers on their infants.
    • The KEH scale could also identify effects related to prematurity, hypoxia, or delivery trauma.