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Updated: Jul 31, 2026
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An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
Invasive bladder carcinoma managed by irradiation and surgery
Urology
|November 1, 1982
Summary
Preoperative irradiation and surgery for invasive bladder cancer showed improved survival for patients with no residual disease or low-stage cancer. High-stage cancer patients had significantly lower survival rates, indicating a need for new treatments.
Area of Science:
- Urology
- Oncology
- Surgical Oncology
Background:
- Invasive bladder cancer presents a significant treatment challenge.
- Optimizing treatment strategies for bladder carcinoma is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the survival rates of patients with invasive bladder carcinoma treated with preoperative irradiation and surgical extirpation.
- To assess the impact of residual disease and cancer stage on long-term survival.
Main Methods:
- A nonrandomized study included 444 patients with invasive vesical carcinoma.
- 416 patients were available for a two-year statistical study after preoperative irradiation and surgery.
- Survival rates were calculated based on pathologic findings, specifically residual carcinoma and cancer staging.
Main Results:
- Five-year survival was 66% for patients with no residual carcinoma.
- Patients with low-stage carcinoma achieved a 71% five-year survival rate.
- Conversely, patients with high-stage carcinoma had a significantly lower five-year survival rate of 31%.
Conclusions:
- Preoperative irradiation and surgery demonstrate efficacy in select bladder cancer patients.
- Cancer staging is a critical determinant of survival following this treatment regimen.
- The poor outcomes in high-stage disease highlight the urgent need for novel adjuvant therapies.
