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[Experimental study of measles immunity based on an index to neutrophil damage]
Abstract:
Comparative studies for the elucidation of immunologic reactions in vaccination and infectious measles immunity were carried out. The delayed hypersensitivity was evaluated by the test of neutrophil alteration with the specific antigen according to V. N. Fradkin. The results indicate that the vaccine measles virus strain produces immunological alterations in animals accompanied by the development of sensitization to measles antigen. The observed alterations and changes in specific humoral immunity in experimental measles produced by a pathogenic virus are more manifest than those induced by the vaccine strain.
Insights
Measles vaccination induces immunological alterations and sensitization to measles antigen in animals. Infectious measles immunity elicits a stronger immune response than vaccination.
Area of Science:
- Immunology
- Virology
- Vaccinology
Context:
- Investigating immune responses to measles virus.
- Comparing vaccine-induced immunity with natural infection immunity.
Purpose:
- To elucidate and compare immunologic reactions in measles vaccination versus infectious measles immunity.
- To evaluate delayed hypersensitivity using neutrophil alteration tests.
Summary:
- Measles vaccine virus strains induce immunological alterations and sensitization to measles antigen in animal models.
- Experimental measles induced by pathogenic virus shows more pronounced alterations and humoral immunity changes than vaccine strains.
Impact:
- Provides insights into the comparative immunogenicity of measles vaccines and wild-type virus.
- Contributes to understanding delayed hypersensitivity mechanisms in measles immunity.