[Tetracycline ulcer of the esophagus]

On the basis of 3 observations the author deals with acute ulcers in the oesophagus after oral application of oxytetracycline capsules. Sudden retrosternal pains, beginning in most cases during night, are in the foreground of the clinical picture. Discontinuation of the medicament and prescription of an antacid lead to the regression of the ulcer. For the development of such ulcers probably several factors play a role (pH-changes disturbances of motility and cytolysis). Oxytetracycline capsules should be taken always with abundant fluid and not immediately before bedtime.