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[Morphological and functional changes in the reticuloendothelial system in psoriatics]

P Altmeyer, D Munz

    Zeitschrift Fur Hautkrankheiten
    |September 15, 1982
    PubMed
    Summary

    Technetium-99m labeled Human Serum Albumin-Millimicrospheres (99mTc-HSA-MM) aids in visualizing bone marrow and assessing macrophage function in psoriatic patients. Psoriatic patients showed altered bone marrow space and accelerated RES-macrophage turnover.

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    Area of Science:

    • Nuclear Medicine
    • Immunology
    • Dermatology

    Background:

    • Psoriasis is a chronic inflammatory disease with systemic implications.
    • The reticuloendothelial system (RES) and its macrophages play a role in immune responses.
    • Bone marrow visualization and RES function assessment can provide insights into disease mechanisms.

    Purpose of the Study:

    • To evaluate the utility of 99mTc-HSA-MM for bone marrow visualization in psoriatic patients.
    • To explore the phagocytic and proteolytic function of RES-macrophages in psoriatic patients.
    • To compare RES-macrophage turnover in psoriatics with healthy controls and assess the impact of treatment.

    Main Methods:

    • Administration of 99mTc-HSA-MM to 24 psoriatic patients and 24 healthy adults.

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  • Bone marrow imaging to assess bone marrow space.
  • Analysis of 99mTc-HSA-MM turnover in liver, spleen, and bone marrow to evaluate RES-macrophage function.

    • Main Results:

    • 75% of psoriatics exhibited peripheral extension of the bone marrow space, unlike controls.
    • Accelerated 99mTc-HSA-MM turnover in liver, spleen, and bone marrow was observed in 66% of untreated psoriatics.
    • Systemic retinoid treatment or cirrhosis of the liver was associated with delayed HSA-MM turnover.

    Conclusions:

    • 99mTc-HSA-MM is a valuable agent for bone marrow visualization and RES-macrophage function assessment in psoriasis.
    • Psoriasis is associated with distinct bone marrow changes and altered macrophage kinetics.
    • Treatment and comorbidities like liver cirrhosis significantly impact RES-macrophage turnover.