[Genetic analysis of associations of HLA system antigens with schizophrenia]

The HLA antigens were typed in 130 healthy subjects, 87 patients with schizophrenia (35 with continuous, 44 with paroxysmal, and 8 with recurrent form s), and in 145 1st-degree relatives of theirs. The results of the HLA antigens typing pointed to existence of certain genetic differences between the various clinical forms of schizophrenia. The frequency of the "schizophrenia sensitivity" gene localized within the HLA segment was calculated, and two genetic models of inheriting this gene (separately for the paroxysmal and continuous form of schizophrenia) were tested. On the basis of the data on the different frequency of the HLA system antigens in the patients with the paroxysmal and continuous schizophrenia an integrated index for diagnosing these forms of the disease was calculated with the use of discriminant analysis. Besides, another integrated index was calculated on the basis of the family data. This index is intended for medico-genetic consultations and forecasting possible form of schizophrenia in a child (if falls ill) on the basis of typing the HLA antigens in the parents and evaluation of their status.