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Increased blood-brain barrier dysfunction around cerebral stab wounds in rats immunized to brain antigens. A
The extravasation of serum albumin and immunoglobulin G (IgG) was assayed by electroimmunoassay in cerebral cortex homogenates of rats subjected to stab wound injury either 2 weeks after immunisation to brain antigens or without prior immunisation. The amount of IgG in the brain was significantly higher in immunised than in non-immunised rats 3 and 24 h after injury. A significantly enhanced extravasation of albumin in immunised rats was found only after 24 h. It is concluded that immunisation to brain antigens enhances the vulnerability of the blood-brain barrier in rats subjected to stab wound injury.
The extravasation of serum albumin and immunoglobulin G (IgG) was assayed by electroimmunoassay in cerebral cortex homogenates of rats subjected to stab wound injury either 2 weeks after immunisation to brain antigens or without prior immunisation. The amount of IgG in the brain was significantly higher in immunised than in non-immunised rats 3 and 24 h after injury. A significantly enhanced extravasation of albumin in immunised rats was found only after 24 h. It is concluded that immunisation to brain antigens enhances the vulnerability of the blood-brain barrier in rats subjected to stab wound injury.