Ovarian hypoplasia with follicular calcifications

The clinical features and the ovary biopsy findings of two cases of ovarian hypoplasia are presented. Both patients, 20 and 34 years of age, complained of primary amenorrhea. One patient presented growth retardation with genital and breast infantilism. The other patient, who received substitutive estrogen therapy, displayed normal adult secondary sexual characteristics. The chromosomal karyotype was 46,XX in both patients. The internal genital organs were hypoplastic. In the ovaries, the follicular maturation did not go beyond the secondary follicles which underwent atresia with a strange process of calcification beginning in the ova. The etiologic factors of this phenomenon are unknown. The authors found only one analogous case in the literature.