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Amyloidosis complicating hairy cell leukemia

J Linder, H R Silberman, B P Croker

    American Journal of Clinical Pathology
    |December 1, 1982
    PubMed
    Summary

    Hairy cell leukemia can lead to secondary amyloidosis, a kidney complication. This condition involves protein deposits in the kidneys, causing renal failure and requiring consideration in patient diagnosis.

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    Area of Science:

    • Nephrology
    • Hematology
    • Pathology

    Background:

    • Hairy cell leukemia is a rare B-cell malignancy.
    • Chronic illnesses can lead to secondary amyloidosis.
    • Renal failure is a serious complication in long-term diseases.

    Observation:

    • A patient with a ten-year history of hairy cell leukemia developed renal failure.
    • Renal biopsy revealed amyloidosis with characteristic deposits in glomeruli and blood vessels.
    • Electron microscopy confirmed the presence of amyloid fibrils.

    Findings:

    • Immunohistochemistry identified the deposits as AA Protein.
    • The findings are consistent with secondary amyloidosis.
    • This case demonstrates a link between hairy cell leukemia and AA Protein amyloidosis.

    Implications:

    • Amyloidosis is a potential complication of hairy cell leukemia.
    • Consider amyloidosis in the differential diagnosis of renal failure in hairy cell leukemia patients.
    • Further research may elucidate the mechanisms linking hairy cell leukemia and secondary amyloidosis.

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