Reversal of end-stage kidney failure in two scleroderma patients treated with anticoagulation

Two patients with progressive systemic sclerosis (scleroderma) developed renal failure which required thrice weekly hemodialysis. While receiving hemodialysis treatments and warfarin, their renal function improved and it was possible to discontinue hemodialysis after 9 mo in Case 1 and after 3 mo in Case 2. The recovery of renal function in these patients suggests therapy with warfarin may play a role in the treatment of scleroderma renal failure.