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Serum estrogen levels in men with acute myocardial infarction
Insights
Serum estradiol levels were elevated in men with coronary heart disease, suggesting a potential role in cardiac events. Estrone levels were elevated in all patient groups, not distinguishing heart disease.
Area of Science:
- Cardiology
- Endocrinology
- Biochemistry
Background:
- Estrogen levels in men are typically low but may fluctuate during illness.
- The role of sex hormones in cardiovascular disease is an area of ongoing research.
Purpose of the Study:
- To investigate serum estradiol and estrone levels in men with and without coronary heart disease (CHD).
- To determine if estradiol or estrone levels can differentiate between CHD patients and controls, including those under physiological stress.
Main Methods:
- Serum samples were collected from four groups of men: myocardial infarction (MI) patients, men with unstable angina, men hospitalized in intensive care without CHD, and healthy controls.
- Hormone levels (estradiol, estrone) were measured and compared across groups.
- Correlations between estradiol and creatine phosphokinase were assessed in MI patients.
Main Results:
- Serum estrone was elevated in all patient groups compared to controls, failing to distinguish CHD.
- Serum estradiol was significantly elevated in men with MI, unstable angina, and those with suspected MI.
- Estradiol levels were not elevated in intensive care patients without CHD, indicating specificity to cardiac conditions.
Conclusions:
- Elevated serum estradiol is associated with confirmed or suspected coronary heart disease in men.
- Estradiol may play a role in the pathophysiology of CHD, potentially by increasing myocardial oxygen demand.
- Estrone levels are not specific indicators for differentiating CHD in men.
Abstract:
Serum estradiol and serum estrone levels were assessed in 29 men in 14 men in whom myocardial infarction was ruled out; in 12 men without apparent coronary heart disease but hospitalized in an intensive care unit; and in 28 men who were not hospitalized and who acted as control subjects. (The 12 men who were hospitalized but who did not have coronary heart disease were included to control for physical and emotional stress of a severe medical illness.) Ages ranged from 21 to 56 years. Age, height, and weight did not differ significantly among groups. Blood samples were obtained in the patient groups on each of the first three days of hospitalization. The serum estrone level was significantly elevated in all four patient groups when compared with that in the control group. Estrone level, then, did not differentiate patients with and without coronary heart disease. Serum estradiol levels were significantly elevated in the groups with myocardial infarction, unstable angina, and in the group in whom myocardial infarction was ruled out. However, estradiol levels were not significantly elevated in the group in the intensive care unit without coronary heart disease when compared to the level in the normal control group. Serum estradiol levels, then, were elevated in men with confirmed or suspected coronary heart disease but were not elevated in men without coronary heart disease even under the stressful conditions found in an intensive care unit. Serum estradiol levels were significantly and positively correlated (p less than 0.03) with serum total creatine phosphokinase levels in the patients with myocardial infarction. The five patients with myocardial infarction who died within 10 days of admission had markedly elevated serum estradiol levels. The potential significance of these serum estradiol elevations is discussed in terms of estradiol's ability to enhance adrenergic neural activity and the resultant increase in myocardial oxygen demand.