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Hepatic damage in experimental and clinical paragonimiasis
The American Journal of Tropical Medicine and Hygiene
|November 1, 1982
Summary
Paragonimus skrjabini causes significant hepatic damage and unique symptoms in humans. This study details its migration and pathological effects in animal models and clinical cases of paragonimiasis.
Area of Science:
- Parasitology
- Hepatology
- Infectious Diseases
Background:
- Paragonimiasis is a parasitic disease caused by lung flukes.
- Hepatic involvement is a less common manifestation of paragonimiasis.
Observation:
- A unique case from Sichuan Province presented with hepatic tenderness, dysfunction, fever, and bloody sputum.
- Diagnosis was confirmed by identifying Paragonimus skrjabini in an abdominal wall bulla.
- Clinical cases from Fujian Province also exhibited hepatic function disturbances.
Findings:
- Experimental infection with P. skrjabini led to acute eosinophilic abscesses and hepatomegaly in laboratory animals.
- Mature worms and eggs were found in hepatic cysts in dogs 3-9 months post-infection.
- P. skrjabini demonstrated a distinct liver migration pattern in dogs, with peak presence by day 14, exceeding that of P. westermani.
Implications:
- Understanding P. skrjabini migration and hepatic pathology is crucial for diagnosing and treating paragonimiasis.
- Hepatic paragonimiasis should be considered in endemic areas with relevant clinical signs.
- Further research into P. skrjabini's host-parasite interactions can inform control strategies.