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Liver scintigraphy in ponies

M C Theodorakis, A J Bermudez, J P Manning

    American Journal of Veterinary Research
    |September 1, 1982
    PubMed
    Summary
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    Six new technetium 99m radiopharmaceuticals showed good liver imaging in ponies. These agents offer a promising alternative to commonly used colloids, avoiding lung uptake issues in equine scintigraphy.

    Area of Science:

    • Nuclear medicine
    • Veterinary radiology
    • Radiopharmaceutical chemistry

    Background:

    • Technetium 99m (99mTc) labeled colloids are standard for liver scintigraphy in many species.
    • However, ponies exhibit significant lung uptake of these colloids, limiting diagnostic accuracy.
    • Novel radiopharmaceuticals are needed for effective equine liver imaging.

    Purpose of the Study:

    • To prepare and evaluate six novel ethylenediamine-N,N'-bis(alpha-2-hydroxy phenyl) acetic acid derivatives labeled with technetium 99m.
    • To assess their scintigraphic imaging qualities for liver structures in ponies.
    • To compare their efficacy with conventional 99mTc-labeled colloids in equine subjects.

    Main Methods:

    • Synthesis of six ethylenediamine-N,N'-bis(alpha-2-hydroxy phenyl) acetic acid derivatives.

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  • Labeling of these derivatives with technetium 99m (99mTc).
  • Evaluation of imaging qualities through scintigraphy in ponies, utilizing various scan views (dorsal, left lateral, right lateral, oblique).

    • Main Results:

    • All six 99mTc-labeled agents produced good scintigraphic images of specific liver structures in ponies.
    • Detailed imaging of liver lobes (left lateral, right lateral, quadrate) was achieved with different scan projections.
    • In contrast, conventional 99mTc-labeled colloids resulted in substantial lung uptake in ponies.

    Conclusions:

    • The developed 99mTc-labeled ethylenediamine derivatives demonstrate excellent potential for equine liver scintigraphy.
    • These agents provide superior visualization of liver anatomy compared to standard colloids in ponies.
    • They represent a valuable advancement for diagnostic imaging in equine hepatobiliary diseases.