Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercapnic ventilatory response in sleeping adults

N J Douglas, D P White, J V Weil

    The American Review of Respiratory Disease
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Trazodone increases arousal threshold in obstructive sleep apnoea.

    The European respiratory journal·2008
    Same author

    Heart rate chaos in obstructive sleep apnea in children.

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
    Same author

    Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.

    Thorax·2006
    Same author

    Sleep. 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.

    Thorax·2004
    Same author

    Variation in human ventilatory control-genetic influence on the hypoxic ventilatory response.

    Respiratory physiology & neurobiology·2003
    Same author

    Chronic mountain sickness. A view from the crow's nest.

    Advances in experimental medicine and biology·2002
    Same journal

    Human lung lysozyme: sources and properties.

    The American review of respiratory disease·2015
    Same journal

    "Immotile-cilia" syndrome and ciliary abnormalities induced by infection and injury.

    The American review of respiratory disease·2013
    Same journal

    Adult criteria for obstructive apnea do not identify children with serious obstruction.

    The American review of respiratory disease·1993
    Same journal

    Cell adhesion molecules and the bronchial epithelium.

    The American review of respiratory disease·1993
    Same journal

    Adhesion molecules and cytokine production.

    The American review of respiratory disease·1993
    Same journal

    Molecular mechanisms mediating lymphocyte recirculation, inflammation, and metastasis formation.

    The American review of respiratory disease·1993
    See all related articles

    The hypercapnic ventilatory response (HCVR) is significantly reduced during sleep, especially during rapid eye movement (REM) sleep. This diminished response to high carbon dioxide levels contributes to hypoxemia during REM sleep.

    Area of Science:

    • Physiology
    • Sleep Science
    • Respiratory Control

    Background:

    • Hypoventilation, hypoxia, and hypercapnia are characteristic of Rapid Eye Movement (REM) sleep.
    • Reduced hypoxic ventilatory response during REM sleep is known, but hypercapnic ventilatory response (HCVR) remains unstudied in adults.

    Purpose of the Study:

    • To investigate the hypercapnic ventilatory response (HCVR) during different sleep stages in adult humans.
    • To determine if HCVR is altered during non-REM and REM sleep compared to wakefulness.

    Main Methods:

    • Twelve healthy adults underwent polysomnography with ventilatory response measurements.
    • A modified rebreathing method was used to assess the ventilatory response to hypercapnia during wakefulness, non-REM, and REM sleep.

    Related Experiment Videos

    Main Results:

    • HCVR was significantly reduced in all sleep stages compared to wakefulness.
    • During non-REM sleep, HCVR was less than half of the waking response.
    • During REM sleep, HCVR dropped to less than one-third of the waking response.

    Conclusions:

    • The hypercapnic ventilatory response is substantially blunted during both non-REM and REM sleep in adults.
    • The further significant reduction in HCVR during REM sleep contributes to REM-related hypoxemic episodes.