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Local cerebral glucose utilization in the newborn macaque monkey

C Kennedy, O Sakurada, M Shinohara

    Annals of Neurology
    |October 1, 1982
    PubMed
    Summary

    Newborn macaque brains show varied glucose utilization, with auditory pathways at mature levels. This study used the [14C]deoxyglucose method to map brain metabolism in infant primates.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Primate Research

    Background:

    • Local cerebral glucose utilization (LCGU) is a key indicator of brain function.
    • Understanding LCGU in developing brains is crucial for identifying developmental trajectories and potential abnormalities.

    Purpose of the Study:

    • To quantitatively determine LCGU in newborn macaque monkeys using the [14C]deoxyglucose method.
    • To compare glucose utilization patterns in neonates with those in pubescent and mature macaques.
    • To investigate the metabolic maturation of specific sensory pathways, including auditory and visual systems.

    Main Methods:

    • Utilized the quantitative [14C]deoxyglucose autoradiography method.
    • Measured local cerebral glucose utilization across various brain structures in newborn macaque monkeys.
    • Correlated glucose utilization with local cerebral blood flow measured using [14C]antipyrine.

    Main Results:

    • Observed a wide range of LCGU values, from 14 to 180 mumol/100 gm/min, exceeding the range found in pubescent monkeys.
    • Found that lower neuraxis structures met or exceeded mature levels, while midbrain-superior structures were generally lower.
    • The auditory system exhibited mature or exceeding levels throughout, while the visual system showed variable cortical rates but preserved subcortical and striate cortex laminae.
    • White matter glucose utilization was elevated compared to mature levels, particularly in the brainstem and cerebellum.
    • Demonstrated a strong correlation (r=0.92) between LCGU and local cerebral blood flow.

    Conclusions:

    • Newborn macaque brain metabolism displays distinct patterns compared to older animals, with significant regional variations.
    • The auditory system shows precocious development, reaching mature metabolic levels at birth.
    • The visual system exhibits a more protracted maturation, with specific structures like the striate cortex showing differential metabolic activity.
    • These findings provide a metabolic map of the developing primate brain, essential for understanding neurodevelopment.

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