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Late-onset peripheral joint disease in ankylosing spondylitis
Annals of the Rheumatic Diseases
|December 1, 1982
Summary
Late-onset peripheral arthritis can develop in patients with ankylosing spondylitis even after spinal disease remits. This condition may cause significant joint deformity, necessitating aggressive treatment strategies.
Area of Science:
- Rheumatology
- Immunology
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
- Peripheral arthritis is a common manifestation in AS, but its onset relative to axial disease activity is not fully understood.
Observation:
- A review of 150 seronegative ankylosing spondylitis patients with peripheral arthritis was conducted.
- Seven patients (4.7%) exhibited late-onset peripheral arthritis, appearing after their spinal disease had become inactive.
Findings:
- Late-onset peripheral arthritis occurred in a subset of patients with established ankylosing spondylitis.
- This late manifestation can lead to substantial joint deformity.
Implications:
- The findings suggest that peripheral arthritis in ankylosing spondylitis may have a delayed onset independent of axial disease activity.
- Aggressive therapeutic interventions may be required to manage late-onset peripheral arthritis and prevent joint damage.