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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
[Echocardiographic study of chronic aortic insufficiency. Hemodynamic, angiographic and total clinical correlates.
Abstract:
An important point in the evolution of chronic aortic insufficiency (CAI) is the degree of disturbance of left ventricular performance (LVP), from which the surgical risk and the prognosis depend. Is possible by M mode Echocardiography (M-Echo) to evaluate the different elements that regulate the LVP, with the known measurements and by ratios of integral appraisal that are described here. We studied 14 patients with pure CAI at the National Institute of Cardiology, all of them had left catherization, ventriculography aortography, M-Echo, Chest X ray and EKG. The end systolic diameter (ESD) of the left ventricle (LV) and the fractional shortening (FS) showed good correlation with the end diastolic pressure (EDP) of the LV (r = 0.86 and -0.74 respectively). The percentage of aortic regurgitation (%AR) did not show significative correlation with the parameters of LV function. The ratios of integral appraisal showed good correlation with the EDP of the LV, the left atrium diameter over ejection fraction ratio (LAD/EF) was r = 0.764; the E point-septum separation over the fractional shortening ratio (E-S/FE) was r = 0.776, and for the ESD over the normalized velocity of the posterior wall of the LV ratio (ESD/NVPW) was r = 0.85. The relationship of the ESD/NVPW ratio with the EF was good (r = 0.95), with the mean velocity of circunferential shortening (r = -0.94) and with the cardiothoracic index (r = 0.88). We did not find a relationship between the functional class (NYHA) and the LVP, evaluated hemodynamic and echocardiographic methods used here. The M-Echo is an useful procedure for the sequential study of CAI, that permits recognition of the initiation and severity of the LV dysfunction, and it is of great help to signal the right moment for the surgical treatment.
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