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Is dextran 70 a lymphocyte mitogen?

A C Burden, R L Stacey, R Windle

    Lancet (London, England)
    |October 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Dextran 70 significantly increases lymphocyte blastogenesis at specific concentrations, suggesting it may act as a B-cell mitogen. These findings highlight potential clinical relevance for this widely used substance.

    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • Dextran 70 (Lomodex) is a widely used substance with potential biological effects.
    • Investigating its impact on immune cell function is crucial for understanding its clinical relevance.

    Purpose of the Study:

    • To evaluate the effect of Dextran 70 on lymphocyte blastogenesis.
    • To determine if Dextran 70 acts as a mitogen for B-cells.

    Main Methods:

    • A modified whole-blood method was used to assess lymphocyte blastogenesis.
    • Thymidine incorporation was measured to quantify lymphocyte proliferation.

    Main Results:

    • Dextran 70 induced significant thymidine incorporation at molar concentrations of 7 X 10(-6) and 7 X 10(-5) mol/l.
    • At 7 X 10(-7) mol/l, Dextran 70 alone did not increase incorporation, but significantly enhanced it when added with phytohaemagglutinin (PHA).

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  • Pre-incubation with Dextran 70 prior to PHA decreased thymidine incorporation.

    • Conclusions:

    • The variable effects of Dextran 70 on lymphocyte blastogenesis suggest it may function as a B-cell mitogen.
    • The observed immunomodulatory effects of Dextran 70 warrant further investigation for clinical implications.