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Effects of L-ascorbic acid supplementation on dieldrin toxicity in rats
Archives of Toxicology
|September 1, 1982
Summary
Chronic dieldrin exposure causes liver and kidney damage in rats. L-ascorbic acid supplementation helped prevent these toxic effects and normalize enzyme activities.
Area of Science:
- Environmental toxicology
- Biochemistry
- Pathology
Background:
- Dieldrin is an organochlorine pesticide with known toxicity.
- Chronic exposure can lead to organ damage and biochemical alterations.
Purpose of the Study:
- To investigate the pathological and biochemical effects of chronic dieldrin exposure in rats.
- To evaluate the protective role of L-ascorbic acid against dieldrin toxicity.
Main Methods:
- Rats were administered dieldrin (5 mg/kg/day) chronically.
- Biochemical assays were performed on liver and kidney tissues.
- Histological examination of tissues was conducted.
- L-ascorbic acid was administered to supplemented groups.
Main Results:
- Dieldrin caused pathological changes in liver and kidney tissues.
- Elevated liver ascorbic acid and altered enzyme activities (inorganic pyrophosphatase, glucose-6-phosphatase, Mg2+-ATPase, acetylcholinesterase) were observed.
- L-ascorbic acid supplementation partially reversed histological damage and normalized some enzyme activities.
Conclusions:
- Chronic dieldrin exposure induces significant liver and kidney pathology and biochemical disturbances in rats.
- L-ascorbic acid demonstrates a protective effect against dieldrin-induced toxicity.