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Effectiveness of generic acetazolamide

P P Ellis, P K Price, R Kelmenson

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |December 1, 1982
    PubMed
    Summary
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    Generic and brand-name acetazolamide show equivalent ocular hypotensive effects and blood levels. Generic acetazolamide is 37% less expensive, and food intake does not affect acetazolamide absorption.

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Acetazolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure.
    • Generic formulations are often more affordable alternatives to brand-name drugs.

    Purpose of the Study:

    • To compare the ocular hypotensive efficacy and pharmacokinetics of generic acetazolamide versus brand-name acetazolamide (Diamox).
    • To evaluate the cost-effectiveness of generic acetazolamide.
    • To assess the impact of food on acetazolamide absorption.

    Main Methods:

    • Single-dose administration of generic and brand-name acetazolamide.
    • Measurement of intraocular pressure and serum acetazolamide levels.
    • Cost analysis of both formulations.
    • Evaluation of acetazolamide absorption with and without food.

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    Main Results:

    • Both generic and brand-name acetazolamide demonstrated equivalent effects on reducing intraocular pressure.
    • Comparable serum acetazolamide concentrations were achieved with both formulations.
    • Generic acetazolamide was found to be 37% less costly than the brand-name version.
    • Food intake did not significantly influence acetazolamide absorption.

    Conclusions:

    • Generic acetazolamide provides a therapeutically equivalent and more cost-effective alternative to brand-name acetazolamide.
    • The findings support the use of generic acetazolamide for managing intraocular pressure.
    • Acetazolamide absorption is not significantly affected by food consumption.