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Pharmacokinetics of theophylline: a dose-range study
British Journal of Clinical Pharmacology
|December 1, 1982
Summary
Theophylline absorption and elimination followed first-order kinetics in healthy adults across tested doses. Pharmacokinetic parameters remained consistent, indicating predictable theophylline drug behavior.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Theophylline is a widely used bronchodilator.
- Understanding its pharmacokinetic profile is crucial for safe and effective dosing.
Purpose of the Study:
- To investigate the pharmacokinetics of theophylline after single oral administration.
- To determine dose-proportionality and identify potential dose-dependent effects.
Main Methods:
- Healthy adult volunteers received single oral doses of theophylline (125-500 mg).
- Plasma concentrations were analyzed using a one-compartment open model.
- Urinary excretion of theophylline and its metabolites was quantified.
Main Results:
- Theophylline absorption was rapid and followed first-order kinetics.
- A linear relationship was observed between dose and Cmax/AUC.
- Key pharmacokinetic parameters (t1/2, CL, Vd, F) were dose-independent.
Conclusions:
- Theophylline exhibits dose-proportional pharmacokinetics following single oral administration.
- Elimination follows first-order kinetics within the studied dose range.
- The drug's pharmacokinetic parameters are consistent across various doses in healthy adults.