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Updated: Aug 8, 2026
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
[Reaction of rat peritoneal mesothelial cells in aseptic and bacterial peritonitis]
Abstract:
Transmission and scanning electron microscopy were used to examine mesothelial cells of the rat peritoneum in aseptic peritonitis caused by intraperitoneal starch injections and in bacterial peritonitis induced by injury to the large intestine. Active contraction of the mesotheliocytes was recorded in early stages of both the types of peritonitis. In aseptic peritonitis, that contraction was replaced by relaxation of the cells, whereas in bacterial peritonitis, by dystrophy and desquamation.
Insights
Mesothelial cells in rat peritonitis initially contract. Aseptic peritonitis leads to relaxation, while bacterial peritonitis causes cell damage and shedding.
Area of Science:
- Cell biology
- Pathology
- Microscopy
Background:
- Peritonitis is inflammation of the peritoneum.
- Mesothelial cells line the peritoneal cavity and play a role in immune response.
- Understanding mesothelial cell behavior is crucial for peritonitis treatment.
Purpose of the Study:
- To investigate the ultrastructural changes in rat peritoneal mesothelial cells during aseptic and bacterial peritonitis.
- To compare the cellular responses to different types of peritonitis.
Main Methods:
- Transmission and scanning electron microscopy were employed.
- Studies were conducted on rat peritoneum models.
- Aseptic peritonitis was induced by starch injections.
- Bacterial peritonitis was induced by large intestine injury.
Main Results:
- Mesothelial cells exhibited active contraction in the early stages of both peritonitis types.
- In aseptic peritonitis, contraction was followed by cell relaxation.
- Bacterial peritonitis led to mesothelial cell dystrophy and desquamation (shedding).
Conclusions:
- Mesothelial cell response differs significantly between aseptic and bacterial peritonitis.
- Cellular contraction followed by relaxation characterizes aseptic peritonitis.
- Cellular dystrophy and desquamation indicate severe damage in bacterial peritonitis.
