[Cholinergic mechanism of cardiac function regulation in acute transient coronary failure]

Experiments on 120 non-inbred white male rats weighing 200 +/- 10 g have shown phasic changes in the function of the cholinergic regulation mechanism of cardiac activity under the development of local transitory myocardial ischemia. It was characterized by activation of parasympathetic neuroeffector influences (as evaluated from the myocardial acetylcholine content) within the first 40 minutes of coronary occlusion and during reperfusion after 10 and 40 minutes of ischemia as well as by reduction of the influences by the 120th minute of myocardial ischemia and in the course of subsequent reperfusion. At the same time phasic reconstruction was recorded of cholinoreactive function of the heart: an increase during ischemia and a tendency towards reduction during subsequent reperfusion.