Spread of acetylcholine sensitivity in the neocortex following lesion of the nucleus basalis

Neuronal responses to the iontophoretic application of acetylcholine, carbachol and nicotine were studied in rats, 2 or 3 weeks following bilateral lesions of the nucleus basalis region, and compared to those obtained in normal animals. The percentage of cortical neurons excited by acetylcholine and their individual sensitivity were higher in lesioned animals. Furthermore, the laminar distribution of the responses to acetylcholine and the proportion of responses to carbachol and nicotine were also modified.