Glutathione peroxidase in human cerebrospinal fluid

Glutathione peroxidase activity was investigated in human cerebrospinal fluid. CSF was obtained from 23 male adult patients with dementia, cerebrovascular disease and multiple sclerosis. The mean glutathione peroxidase activity in the CSF was 6.2 nmol NADPH oxidized min-1 . mg-1 protein +/- 0.6 S.E.M. No differences in the activities were observed in these neurological diseases suggesting that this value may reflect normal glutathione peroxidase activity in human CSF. The age or the protein concentration in CSF did not correlate significantly with glutathione peroxidase activity in CSF.