Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaesthetic induction for Caesarean section with propanidid

M C Mahomedy, J W Downing, D E Jeal

    Anaesthesia
    |March 1, 1976
    PubMed
    Summary

    Propanidid anesthesia during Cesarean sections resulted in higher fetal acidosis and lower oxygen levels compared to thiopentone. Some mothers also experienced painful recall, indicating propanidid did not meet expectations for obstetric anesthesia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A model of the UV skin dose distribution in paediatric whole-body phototherapy.

    Physics in medicine and biology·2021
    Same author

    A thermal radiation exchange model of whole-body UV phototherapy.

    Biomedical physics & engineering express·2021
    Same author

    Interprofessional education in dentistry.

    British dental journal·2018
    Same author

    Oxygenating laryngoscopy.

    Anaesthesia·2016
    Same author

    Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model.

    Translational psychiatry·2016
    Same author

    Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma.

    Computer aided surgery : official journal of the International Society for Computer Aided Surgery·2014

    Area of Science:

    • Anesthesiology
    • Obstetrics
    • Perinatal Medicine

    Background:

    • Cesarean sections require careful anesthetic management to ensure maternal and fetal well-being.
    • Evaluating new anesthetic agents like propanidid is crucial for optimizing obstetric anesthesia.
    • Thiopentone has been a traditional choice, necessitating comparative studies for alternative agents.

    Purpose of the Study:

    • To compare the effects of propanidid versus thiopentone anesthesia on maternal and fetal blood gases during Cesarean sections.
    • To assess the clinical status of neonates born after propanidid-induced anesthesia.
    • To evaluate the incidence of maternal awareness and recall with propanidid.

    Main Methods:

    • Fifty healthy mothers undergoing Cesarean section received propanidid for anesthesia induction.

    Related Experiment Videos

  • Anesthesia was maintained with nitrous oxide, oxygen, muscle relaxants, and controlled ventilation, with lateral tilt to prevent aortocaval occlusion.
  • Maternal and umbilical cord blood samples were analyzed for blood gases and acid-base status; neonate status was assessed using the Apgar score.

    • Main Results:

    • Propanidid anesthesia was associated with significantly lower umbilical venous and arterial pH values and higher base deficits compared to thiopentone.
    • Mean oxygen levels in umbilical cord blood were significantly lower in the propanidid group.
    • Six percent of patients receiving propanidid reported painful factual recall during surgery.

    Conclusions:

    • Propanidid administration during Cesarean sections led to increased fetal acidaemia and reduced oxygenation compared to thiopentone.
    • The incidence of painful maternal recall suggests a significant drawback of propanidid in obstetric anesthesia.
    • Despite theoretical advantages, propanidid did not prove superior to thiopentone for Cesarean section anesthesia in this study.