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Related Experiment Video

Updated: Feb 10, 2026

Electroretinogram Recording for Infants and Children under Anesthesia to Achieve Optimal Dark Adaptation and International Standards

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The pupil dark response in narcolepsy

C R Kollarits, J Lechman, F J Kollarits

Current Eye Research

|January 1, 1982

Summary

Pupil responses to darkness were similar in narcoleptic patients and normal individuals. Pupillography cannot reliably distinguish between these groups, despite some narcoleptics falling asleep during testing.

Area of Science:

Ophthalmology
Neurology
Sleep Medicine

Background:

Narcolepsy is a chronic neurological disorder affecting the brain's ability to regulate sleep-wake cycles.
Previous research suggested pupillography might differentiate narcoleptic patients from healthy individuals.

Purpose of the Study:

To compare the pupil dark response in narcoleptic patients versus normal volunteers.
To evaluate the utility of pupillography in distinguishing narcolepsy.

Main Methods:

Pupil dark response and pupil area maintenance in darkness were measured.
Seven narcoleptic patients and 14 age-matched normal volunteers participated.

Main Results:

Onset and degree of miosis (pupil constriction) were similar between narcoleptic patients and normal volunteers.

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Three narcoleptic patients, but no normal volunteers, fell asleep during the pupillography tests.

Conclusions:

Pupillography is not a reliable method for distinguishing narcoleptic patients from normal individuals.
Findings contradict earlier suggestions regarding the diagnostic value of pupillography in narcolepsy family studies.