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Prophylactic netilmicin in surgery

A M Abbas, R B Jones, C C Rigby

    Current Medical Research and Opinion
    |January 1, 1982
    PubMed
    Summary
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    Netilmicin effectively prevented post-operative infections in surgical patients. This antibiotic, netilmicin, proved well-tolerated and reduced hospital stays, offering cost savings.

    Area of Science:

    • Clinical Medicine
    • Pharmacology
    • Infectious Diseases

    Background:

    • Post-operative infections pose a significant risk in surgical patients.
    • Aminoglycosides are commonly used for infection prophylaxis.
    • Nephrotoxicity is a concern with certain aminoglycosides.

    Purpose of the Study:

    • To evaluate the efficacy and safety of netilmicin as a prophylactic antibiotic in surgical patients.
    • To assess the impact of netilmicin prophylaxis on post-operative infection rates.
    • To compare the tolerability and potential nephrotoxicity of netilmicin with other aminoglycosides.

    Main Methods:

    • Seventy-seven surgical patients received prophylactic netilmicin (150 mg IM) 1 hour pre-operation, with 12-hourly dosing thereafter.
    • Patients were monitored for microbiological and clinical evidence of post-operative infection.

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  • Serum levels of netilmicin were monitored, and its tolerability, including nephrotoxicity, was assessed.

    • Main Results:

    • No post-operative infections were observed in general surgical or orthopedic patients.
    • Netilmicin demonstrated good tolerability and serum levels within expected ranges.
    • The prophylactic use of netilmicin appeared to be less nephrotoxic compared to other aminoglycosides.

    Conclusions:

    • Netilmicin is an effective and well-tolerated prophylactic antibiotic for surgical patients.
    • Prophylactic netilmicin can reduce the incidence of post-operative infections.
    • The use of netilmicin may lead to shorter patient bed-stays and reduced healthcare costs.