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Pharmacokinetics and metabolism of naproxen in children

R E Kauffmann, R O Bolliger, S H Wan

    Developmental Pharmacology and Therapeutics
    |January 1, 1982
    PubMed

    Insights

    Naproxen

    Area of Science:

    • Pharmacology
    • Pediatric Medicine
    • Drug Metabolism

    Background:

    • Naproxen is a common nonsteroidal anti-inflammatory drug (NSAID).
    • Understanding its pharmacokinetics in children is crucial for safe and effective dosing.

    Purpose of the Study:

    • To investigate the metabolism and pharmacokinetics of oral naproxen in children.
    • To compare naproxen's absorption and elimination in febrile versus postoperative pediatric patients.

    Main Methods:

    • Oral naproxen administration to 10 children (aged 6-13 years).
    • Analysis of drug and metabolite excretion in urine.
    • Comparison of pharmacokinetic parameters between patient groups.

    Main Results:

    • Higher elimination rate constant in febrile children (0.064 h-1) compared to postoperative patients (0.051 h-1).
    • Naproxen and its desmethyl metabolite were excreted as conjugates.
    • Reduced area under the curve and urinary drug recovery in postoperative patients, indicating potentially lower gastrointestinal absorption.

    Conclusions:

    • Naproxen exhibits distinct pharmacokinetic profiles in pediatric patients based on their condition (fever vs. postoperative pain).
    • Gastrointestinal absorption may be reduced in postoperative pediatric patients compared to those with fever.
    • Further research is warranted to optimize naproxen dosing in pediatric populations.

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