Amino acid sequence around the active site of two class I fructose-1,6-bisphosphate aldolases from staphylococci

The amino acid sequences of a 26-residue segment containing the active-site lysyl residue of the class I fructose-1,6-bisphosphate aldolases from Staphylococcus aureus and Staphylococcus epidermidis have been determined. The sequence homology within the active sites between these enzymes and those from several eucaryotic class I aldolases showed a maximum of 21%. The similarity may indicate the origin of both procaryotic and eucaryotic class I aldolases from a common ancestor.