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Updated: Oct 2, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
[Antifungal activity of diesters of 2-mercaptobenzene methanethiol]
Abstract:
Some diesters of 2-mercaptobenzenmethanthiol and of 2-(2-nitrophenyl)-1,3-benzodithiyne were prepared and tested for in vitro antifungal activity. The substances [Table I: substances (I leads to VIII)] were obtained by condensation of 2-mercaptobenzenmethanthiol with suitable reagents. The antifungal activity of the products was tested in vitro against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. It was found that antimycotic activity is shown by only some of the diesters of 2-mercaptobenzenmethanthiol with acyl alkylthiocarbamic groups (Table I). The diesters with aliphatic, aromatic, alkylcarbamic groups and the 2-(2-nitrophenyl)-1,3-benzodithiyne are inactive or only slightly active.
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