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[Changes in lymphocytes caused by aldosterone and a spironolactone derivative. Animal experiments and clinical
Fortschritte Der Medizin
|November 4, 1982
Abstract:
In animal experiments marked and characteristic changes of lymphocytes could be observed with electronmicroscopic methods due to aldosterone and potassium canrenoate. These results may be a further reference to an immunosuppressive effect of aldosterone and spirolactone derivates. The electronmicroscopic study of thoracic duct cells of a patient suffering from multiple sclerosis and treated with aldosterone and potassium canrenoate showed changes of the morphological structure of small lymphocytes, which was interpreted with a lymphoclastic effect of this substances on lymphocytes.