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Related Experiment Videos

[Therapy using delayed-action theophylline]

W T Ulmer, I Zimmermann

    Fortschritte Der Medizin
    |November 11, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Theophylline effectively reduced the need for beta 2-sympathomimetics in patients with airway obstruction. This study demonstrates the bronchodilator benefits of theophylline in managing respiratory conditions.

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    Area of Science:

    • Pharmacology
    • Respiratory Medicine
    • Clinical Trials

    Context:

    • Airway obstruction significantly impacts respiratory function.
    • Beta 2-sympathomimetics are commonly used for bronchodilation.
    • Theophylline's role in managing airway obstruction requires further clinical evaluation.

    Purpose:

    • To assess the efficacy of sustained-release theophylline in patients with varying degrees of airway obstruction.
    • To evaluate the potential reduction in beta 2-sympathomimetic aerosol use with theophylline treatment.
    • To determine theophylline serum levels achieved in different patient groups.

    Summary:

    • A 6-day clinical study involved 10 patients with airway obstruction, divided into severe (Group A) and slight (Group B) obstruction groups.

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  • Patients received sustained-release theophylline (Afonilum retard, 250 mg).
  • Theophylline demonstrated a significant bronchodilator effect, reducing beta 2-sympathomimetic aerosol use from 12 to 2-4 puffs/day. Mean theophylline serum levels were 7.5 mcg/ml (Group A) and 11.0 mcg/ml (Group B).

    • Impact:

    • Theophylline can be an effective adjunct therapy for airway obstruction, reducing reliance on rescue inhalers.
    • Clinical findings support theophylline's bronchodilator properties in managing respiratory distress.
    • This study provides evidence for optimizing theophylline dosage for therapeutic effect while monitoring serum levels.