Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Technetium-99m generators--the available options

R E Boyd

    The International Journal of Applied Radiation and Isotopes
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This review compares methods for separating technetium-99m (99mTc) from molybdenum-99 (99Mo), highlighting advantages of neutron-activation production over fission-produced 99Mo for 99mTc generators.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Accumulation of Insensitive Munition Compounds in the Earthworm Eisenia andrei from Amended Soil: Methodological Considerations for Determination of Bioaccumulation Factors.

    Environmental toxicology and chemistry·2021
    Same author

    Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

    Molecular psychiatry·2014
    Same author

    Investigations of tungsten mobility in soil using column tests.

    Chemosphere·2009
    Same author

    Geochemical parameters influencing tungsten mobility in soils.

    Journal of environmental quality·2008
    Same author

    Alpha2-adrenergic receptor agonists as analgesics.

    Current topics in medicinal chemistry·2002
    Same author

    Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes.

    Journal of medicinal chemistry·2001
    Same journal

    Comparison of infrared and mass-spectrometric measurements of carbon-13/carbon-12 ratios.

    The International journal of applied radiation and isotopes·1985
    Same journal

    Microbiological and chemical studies on irradiated black pepper.

    The International journal of applied radiation and isotopes·1985
    Same journal

    Dosimetry of gamma rays from nitrogen-16 decay.

    The International journal of applied radiation and isotopes·1985
    Same journal

    Mild and regiospecific synthesis of 18F-labelled vinyl fluoride using [18F]fluorine reacted with silane.

    The International journal of applied radiation and isotopes·1985
    Same journal

    Effect of the Tc-nitrido group on the behaviour of 99mTc-radiopharmaceuticals.

    The International journal of applied radiation and isotopes·1985
    Same journal

    Radioimmunoassay of Pinellia ternata lectin.

    The International journal of applied radiation and isotopes·1985
    See all related articles

    Area of Science:

    • Radiochemistry
    • Nuclear Medicine
    • Chemical Engineering

    Background:

    • Technetium-99m (99mTc) is a crucial medical radioisotope.
    • Its parent, molybdenum-99 (99Mo), is primarily produced via nuclear fission.
    • Fission-based 99Mo production presents challenges including high costs and radioactive waste.

    Purpose of the Study:

    • To review and compare common 99mTc/99Mo generator separation methods.
    • To evaluate the suitability of different 99Mo production routes for 99mTc users.
    • To explore alternatives to fission-produced 99Mo.

    Main Methods:

    • Review of established separation techniques: chromatography, sublimation, and solvent extraction.
    • Comparative analysis of different 99mTc generator systems.

    Related Experiment Videos

  • Discussion of 99Mo production methods and their impact on generator choice.

    • Main Results:

    • Chromatography, sublimation, and solvent extraction are key 99mTc separation methods.
    • The choice of 99Mo production method influences the optimal generator system.
    • Neutron-activation produced 99Mo offers an attractive alternative to fission-produced 99Mo, especially where resources are limited.

    Conclusions:

    • Advancements in generator technology favor neutron-activation produced 99Mo.
    • Alternative 99Mo production methods may reduce reliance on fission processes.
    • Future trends suggest neutron-activation may become a preferred route for 99mTc production.