Lower-oxidation-state 99mTc in the generator product--its determination and occurrence

The behaviour of some [99mTc]chlorocomplexes in NaCl solution is described. These compounds of lower-oxidation-state 99mTc are considered as radiochemical impurities in the injection of [99mTc]sodium pertechnetate. This paper reviews some methods for the separation of 99mTc-compounds and the reliability of these methods with respect to the formation of artifacts. Finally, the questions of why and when the radiochemical purity of Na99mTcO4 injection should be controlled are discussed.