Methods for evaluating optimal dosage regimens and their application to theophylline

Area of Science:

• Pharmacology
• Therapeutic Drug Monitoring

Background:

• Blood drug levels are crucial for monitoring therapy in certain drug classes.
• Establishing optimal treatment schemes requires defined dosing strategies.

Purpose of the Study:

• To present criteria for optimal treatment schemes based on a target concentration strategy.
• To evaluate the performance of these criteria in dose regimen assessment.

Main Methods:

• Developing criteria for dose regimens to achieve target drug concentrations.
• Evaluating performance indices of the proposed criteria.
• Applying criteria to assess theophylline dose regimens.

Main Results:

• Criteria were defined to guide dose regimens towards target concentration ranges.
• Performance of the criteria was evaluated for therapeutic drug monitoring.
• Theophylline dose regimens were assessed using the developed criteria.

Conclusions:

• The target concentration strategy provides a framework for optimizing drug dosing.
• The defined criteria are effective for assessing dose regimens and ensuring therapeutic drug levels.
• This approach enhances the monitoring of drug therapy for improved patient outcomes.