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Related Experiment Videos

Extracorporeal circulation with perfluorochemicals (Fluosol-DA)

S Hoshino, F Iwaya, T Igari

    The Journal of Cardiovascular Surgery
    |November 1, 1982
    PubMed
    Summary

    This study investigated Fluosol-DA's oxygen delivery during extracorporeal circulation (ECC) in calves. Fluosol-DA effectively delivered oxygen, but high retention levels were linked to complications like hemolysis.

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    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Research
    • Perfusion Technology

    Background:

    • Extracorporeal circulation (ECC) requires oxygenated perfusates.
    • Perfluorochemicals (PFCs) like Fluosol-DA offer oxygen-carrying potential.
    • Understanding PFC distribution and complications is crucial for clinical application.

    Purpose of the Study:

    • To evaluate the oxygen carrying capacity of Fluosol-DA during ECC.
    • To examine the organ distribution of Fluosol-DA.
    • To identify potential complications associated with Fluosol-DA use in ECC.

    Main Methods:

    • Experimental study using eight calves undergoing ECC.
    • Blood volume replacement with Fluosol-DA as perfusate.
    • Monitoring of hematocrit, hemoglobin, and Fluosol-DA levels (Fluorocrit).

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  • Measurement of arterial and venous oxygen partial pressures (PaO2, PvO2).

    • Main Results:

    • Fluosol-DA effectively delivered 67-86% of tissue oxygen consumption.
    • Hemolysis occurred in calves with higher Fluosol-DA retention (13.9 g/kg).
    • Lower retention (10.0 g/kg) was observed in calves without hemolysis.
    • Fluosol-DA was primarily retained in the reticuloendothelial system.

    Conclusions:

    • Fluosol-DA demonstrates significant oxygen carrying capacity during ECC.
    • High Fluosol-DA retention correlates with increased risk of hemolysis.
    • Further research is needed to optimize PFC use and minimize complications in perfusion.