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Related Experiment Videos

Complexed IgE in atopy

J Brostoff, P Johns, D R Stanworth

    Lancet (London, England)
    |October 8, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Researchers found complexed immunoglobulin E (IgE) in patients with hay fever and atopic eczema. This discovery may help explain the causes of atopy.

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    Area of Science:

    • Immunology
    • Allergy Research
    • Clinical Medicine

    Background:

    • Atopic diseases like hay fever and eczema are common.
    • The exact mechanisms causing atopy are not fully understood.
    • Immunoglobulin E (IgE) plays a known role in allergic reactions.

    Purpose of the Study:

    • To investigate the forms of IgE present in patients with atopic conditions.
    • To explore potential links between IgE structure and the aetiology of atopy.

    Main Methods:

    • Serum samples were collected from patients diagnosed with hay fever and/or atopic eczema.
    • Circulating immunoglobulin E (IgE) was analyzed for different molecular weight forms.

    Main Results:

    • High-molecular-weight forms of IgE were detected in the serum of 16 patients.
  • These findings suggest the presence of complexed IgE in atopic individuals.

    • Conclusions:

    • The presence of complexed IgE in atopic patients offers a new perspective on atopy.
    • Further research into these IgE complexes could elucidate the underlying causes of atopic diseases.